The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Gene amplification is a copy number increase of a restricted region of a chromosome arm. It
is prevalent in some tumors and is associated with overexpression of the amplified gene (s) …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Despite efforts to profile prostate cancer, the genetic alterations and biological processes
that correlate with the observed histological progression are unclear. Using laser-capture …

Alteration in DNA copy number is one of the many ways in which gene expression and
function may be modified. Some variations are found among normal individuals, others …

Context Given the highly variable behavior and clinical course of prostate cancer (PCa) and
the multiple available treatment options, a personalized approach to oncologic risk …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

The natural history of prostate cancer is remarkably heterogeneous and, at this time, not
completely understood. The widespread adoption and application of prostate‐specific …

Prostate cancer is clinically heterogeneous, ranging from indolent to lethal disease.
Expression profiling previously defined three subtypes of prostate cancer, one (subtype-1) …