The current paradigm of cancer care relies on predictive nomograms which integrate
detailed histopathology with clinical data. However, when predictions fail, the consequences …

Genetic instability is one of the principal hallmarks and causative factors in cancer. Human
transposable elements (TE) have been reported to cause human diseases, including …

Background Genomic DNA copy number aberrations are frequent in solid tumors, although
the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to …

The fatality of cancer predominantly results from the dissemination of primary tumor cells to
distant sites and the subsequent formation of metastases. During tumor progression, some …

▪ Abstract Altering DNA copy number is one of the many ways that gene expression and
function may be modified. Some variations are found among normal individuals (,,), others …

Background ETS transcription factors regulate important signaling pathways involved in cell
differentiation and development in many tissues and have emerged as important players in …

Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical
prostatectomy. Gleason score, tumour volume, surgical margins and Ki-67 index have the …

Progression of primary prostate cancer to castration-resistant prostate cancer (CRPC) is
associated with numerous genetic and epigenetic alterations that are thought to promote …

BACKGROUND Identifying genomic regions that are commonly deleted or gained in
neoplastic cells is an important approach to identify tumor suppressor genes and …

Fanciulli M, Petretto E, Aitman TJ. Gene copy number variation and common human
disease. Variation in gene copy number is increasingly recognized as a common, heritable …