Abstract The DNA Damage Response (DDR) is a complex network of biological processes
that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic …

Purpose To study an association between IL-6 signaling and resistance to radiotherapy of
prostate cancer (PCa) and explore the molecular mechanisms involved. Methods IL-6 …

The ataxia-telangiectasia mutated/ATM and Rad3-related (ATM/ATR) family proteins are
evolutionarily conserved serine/threonine kinases best known for their roles in mediating the …

Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and
results in progressive neurodegeneration for reasons that remain poorly understood. In …

Abstract Ethnopharmacological relevance The genus Pteris (Pteridaceae) has been used as
a traditional herb for a long time. In particular, Pteris laeta Wall. ex Ettingsh. has been widely …

Abstract The Ataxia Telangiectasia Mutated (ATM)-mediated DNA damage response (DDR)
is a major mechanism of resistance of glioblastoma (GB)-initiating cells (GICs) to …

The DNA damage checkpoint signaling pathway is a highly conserved surveillance
mechanism that ensures genome integrity by sequential activation of protein kinase …

Simple Summary Biliary tract cancers (BTCs) are a rare but deadly group of gastrointestinal
tumors that are often diagnosed in the advanced stages of disease. Despite large studies …

Background Glioblastomas have highly infiltrative growth patterns that contribute to
recurrence and poor survival. Despite infiltration being a critical therapeutic target, no …

Ataxia Telangiectasia (AT) is neurodegenerative syndrome caused by inherited mutations
inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What …