Autosomal recessive ataxia telangiectasia (AT) is characterized by radiosensitivity,
immunodeficiency, and cerebellar neurodegeneration. AT is caused by inactivating …

Experiments that examine the impacts of subnatural background radiation exposure provide
a unique approach to studying the biological effects of low-dose radiation. These …

Phosphorylation of the serine 139 of the histone variant H2AX (γH2AX) is a DNA damage
marker that regulates DNA damage response and various diseases. However, whether …

Ribonucleotide reductase (RNR) is an essential holoenzyme required for de novo synthesis
of dNTPs. The Saccharomyces cerevisiae genome encodes for two catalytic subunits, Rnr1 …

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for
maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions …

Two processes held in delicate balance during the fine tuning of synapse development are
oxidative stress and autophagy: each can promote synapse expansion yet in excess are …

Ataxia-telangiectasia (AT) is a rare genetic disease caused by mutations in the gene
encoding the ATM (ataxia-telangiectasia mutated) protein. Although neuronal degeneration …

The autosomal recessive disease ataxia-telangiectasia (AT) presents with cerebellar
degeneration, immunodeficiency, radiosensitivity, capillary dilatations, and pulmonary …

Aging is the leading cause of the vast majority of all pathologies, ranging from
atherosclerosis to tumors and dementia. It is therefore undisputable that improving the …

Background Glioblastomas have highly infiltrative growth patterns that contribute to
recurrence and poor survival. Despite infiltration being a critical therapeutic target, no …