The prognosis for malignant gliomas remains poor, and new treatments are urgently
needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug …

CPT-11 is a clinically important prodrug that requires conversion into the active metabolite
SN-38, a potent topoisomerase I poison, for antitumor activity. However, SN-38 is rapidly …

Results from randomized clinical trials over the last several years have finally begun to
demonstrate the potential of oncolytic viral therapies to treat a variety of cancers. One reason …

Gene-directed enzyme prodrug therapy (GDEPT) is one of the promising alternatives to
conventional chemotherapy. Suicide gene therapy based anticancer strategy involves …

The combination of the choline binding domain of the amidase N-acetylmuramoyl-L-alanine
(CLytA)-D-amino acid oxidase (DAAO)(CLytA-DAAO) and D-Alanine induces cell death in …

Nonhuman primate embryonic stem (ES) cells have vast promise for preclinical studies.
Genetic modification in nonhuman primate ES cells is an essential technique for maximizing …

Retroviral vector gene therapy is a promising approach to treating HIV-1. However,
integrated vectors are mutagens with the potential to dysregulate nearby genes and cause …

In a new therapy that aims to concentrate and immobilize therapeutic radionuclides in
nanoscale assemblies within solid tumors, a soluble precipitable reagent (SPR) is …

In order to more effectively treat cancer, targeted delivery of therapeutic agents will be
needed. The creation of delivery vehicles capable of locating and entering tumors before …