Although tissue homeostasis—the steady state—implies stability, our organs are in a state of
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …

Frequent exposure to mechanistic damages, pathological ingression, and chronic
inflammation leads to recurrent cell death in the gut epithelium. Intestinal stem cells (ISCs) …

Most genes in higher eukaryotes express isoforms with distinct 3'untranslated regions
(3'UTRs), generated by alternative polyadenylation (APA). Since 3'UTRs are predominant …

Host-microbe interactions influence intestinal stem cell (ISC) activity to modulate epithelial
turnover and composition. Here, we investigated the functional impacts of viral infection on …

Parameters correlated with age and mortality in Drosophila melanogaster include
decreased negative geotaxis and centrophobism behaviors, decreased climbing and …

Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables,
which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic …

The manipulation of cell identity by reprograming holds immense potential in regenerative
medicine, but is often limited by the inefficient acquisition of fully functional cells. This …

Many tumors recapitulate the developmental and differentiation program of their tissue of
origin, a basis for tumor cell heterogeneity. Although stem-cell-like tumor cells are well …

Sea cucumbers have an extraordinary regenerative capability. Under stressful conditions,
Holothuria glaberrima can eviscerate their internal organs, including the digestive tract …

A variety of coordinated host-cell responses are activated as defense mechanisms against
pore-forming toxins (PFTs). Bacillus thuringiensis (Bt) is a worldwide used biopesticide …