Background Low birth weight has been associated with increased risk of type 2 diabetes
mellitus, cardiovascular disease, and hypertension, but the risk at high birth weight levels …

Epidemiological observations have led to the hypothesis that the risk of developing some
chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult …

The “fetal” or “early” origins of adult disease hypothesis was originally put forward by David
Barker and colleagues and stated that environmental factors, particularly nutrition, act in …

The worldwide epidemic of obesity continues unabated. Obesity is notoriously difficult to
treat, and, thus, prevention is critical. A new paradigm for prevention, which evolved from the …

The “small baby syndrome hypothesis” suggests that an inverse linear relation exists
between birth weight and risk of type 2 diabetes. The authors conducted a meta-analysis to …

Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

Pre‐and neonatal overfeeding programmes a permanent obesity disposition and
accompanying diabetic and cardiovascular disorders, by unknown mechanisms. We …

Background In animals, acceleration of neonatal growth is thought to increase the later
propensity to insulin resistance and non-insulin-dependent diabetes, whereas slow growth …

Recent studies in adult and weanling rats show that dietary fat, in close association with
circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling …

Studies in both humans and experimental animals addressing the 'Fetal Origins of Adult
Disease'hypothesis have established a relationship between an adverse intrauterine …