The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

While pain after trauma generally resolves, some trauma patients experience pain for
months to years after injury. An example, relevant to both combat and civilian settings, is …

Unlike physiological stress, which carries survival value, pathological stress is widespread
in modern society and acts as a main risk factor for visceral pain. As the main stress …

Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region.
Due to the complex pathophysiology, it is therapeutically difficult to manage. Noradrenaline …

Neuropathic pain (NP) is known to be associated with abnormal changes in specific brain
regions, but the complex neural network behind it is vast and complex and lacks a …

Chronic pain is induced by tissue or nerve damage and is accompanied by pain
hypersensitivity (ie, allodynia and hyperalgesia). Previous studies using in vivo two-photon …

The transition from acute to chronic pain results in maladaptive brain remodeling, as
characterized by sensorial hypersensitivity and the ensuing appearance of emotional …

Here we studied spinal neurotransmitter mechanisms involved in the reduction of
mechanical hypersensitivity by inhibition of the amygdaloid central nucleus (CeA) in male …

Neuropathic pain is a debilitating chronic condition provoked by a lesion in the nervous
system and it induces functional alterations to the noradrenergic locus coeruleus (LC) …

The parabrachial complex (PB) is critically involved in aversive processes, and chronic pain
is associated with amplified activity of PB neurons in rodent models of neuropathic pain …