1, 2, 3‐Triazole hybrids as anticancer agents: a review
MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …
safer anticancer drugs still need to be developed as the current agents cause unwanted side …
The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1, 2, 3-triazole-chalcone conjugates
Leukemia is a life-threatening nonepithelial malignant disorder that is characterized by
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …
Design and synthesis of novel 1, 2, 3-triazole linked hybrids: Molecular docking, MD simulation, and their antidiabetic efficacy as α-Amylase inhibitors
Abstract Novel 1, 2, 3-triazole linked coumarin and cinnamic acid analogs were designed,
synthesized, characterized, and evaluated for their ability to inhibit the α-amylase enzyme in …
synthesized, characterized, and evaluated for their ability to inhibit the α-amylase enzyme in …
Rationale design, synthesis, cytotoxicity evaluation, and in silico mechanistic studies of novel 1, 2, 3-triazoles with potential anticancer activity
A new set of 1, 2, 3-triazoles was designed and synthesized to evaluate their potential to
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …
[HTML][HTML] Click chemistry in natural product modification
X Zhang, S Zhang, S Zhao, X Wang, B Liu… - Frontiers in Chemistry, 2021 - frontiersin.org
Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access to
the molecular diversity and unique functions of complex natural products up to now. It …
the molecular diversity and unique functions of complex natural products up to now. It …
Design, synthesis, anticancer activity of new amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids: An insights from molecular docking, molecular …
N Gariganti, SK Loke, E Pagadala, P Chinta… - Journal of Molecular …, 2023 - Elsevier
A new series of amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids (9a-j)
have been synthesized and their structures were confirmed by using spectroscopic …
have been synthesized and their structures were confirmed by using spectroscopic …
Design, synthesis, and antiproliferative properties of new 1, 2, 3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors
A new series of substituted aryl carboximidamide VIa-o was designed and synthesised. IR, 1
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
Discovery of triaromatic flexible agents bearing 1, 2, 3-Triazole with selective and potent anti-breast cancer activity and CDK9 inhibition supported by molecular …
This study reports an efficient and convenient click synthesis of novel series of chromene
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …
1, 2, 3-triazole derivatives with anti-breast cancer potential
X Wu, J Wang, S Xia, S Cheng… - Current Topics in …, 2022 - ingentaconnect.com
Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …
of mortality among women across the world. Despite advances in chemotherapy, drug …