Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

The poor translational record of pain research has suggested to some observers that
species differences in pain biology might be to blame. In this review, I consider the evidence …

Objective Cortical spreading depression (SD) is an intense depolarization underlying
migraine aura. Despite the weight of evidence linking SD to the pain phase of migraine …

Background and objective Posttraumatic headache (PTH) is one of the most common,
debilitating and difficult symptoms to manage after a mild traumatic brain injury, or …

Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …

Glucocorticoid-dependent mechanisms of inflammation-mediated distant hippocampal
damage are discussed with a focus on the consequences of traumatic brain injury. The …

The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …

The pain-signaling molecules, nitric oxide synthase (NOS) and calcitonin gene-related
peptide (CGRP), are implicated in the pathophysiology of post-traumatic headache (PTH) as …

Background Frequent mild head injuries or concussion along with the presence of
headache may contribute to the persistence of concussion symptoms. Methods In this study …

Chemotherapy-induced neuropathic pain is one of the major problems for cancer patients.
Although paclitaxel and cisplatin are widely used in women, most laboratory studies of …