Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …

H Mousavi, B Zeynizadeh, M Rimaz - Bioorganic Chemistry, 2023 - Elsevier
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …

Synthesis of novel pyrimido[4,5‐b]quinolines as potential anticancer agents and HER2 inhibitors

NSM Ibrahim, HH Kadry, AF Zaher… - Chemical Biology & …, 2023 - Wiley Online Library
A series of N‐arylpyrimido [4, 5‐b] quinolines 3a–e and 2‐aryl‐2, 3‐dihydropyrimido [4, 5‐b]
quinoline‐4 (1 H)‐ones 5a–e was designed and synthesized as potential anticancer agents …

Synthesis of novel pyrimido[4,5‐b]quinoline derivatives as dual EGFR/HER2 inhibitors as anticancer agents

NSM Ibrahim, HH Kadry, AF Zaher… - Archiv der …, 2024 - Wiley Online Library
A series of novel N‐aryl‐5‐aryl‐6, 7, 8, 9‐tetrahydropyrimido [4, 5‐b] quinolin‐4‐amines 4a–
4l was synthesized as potential anticancer agents through Dimroth rearrangement reaction …

Copper Catalyzed Three-Component Ullmann C–S Coupling in PEG for the Synthesis of 6-Aryl/alkylthio-purines

P Zhang, Y Liu, X Li, G Siri, J Wang, Z Li… - The Journal of …, 2024 - ACS Publications
To tackle the environmental unfriendly issue in existing synthesis strategies for 6-substitued
thiopurine derivatives, such as poor step economy, frequent use of malodorous organic …

Anticancer Activity of New Organotin Complexes with Heterocyclic Thioamides

DA Berseneva, DB Shpakovsky, EA Nikitin… - Russian Journal of …, 2023 - Springer
New complexes I–IV of di-tert-butyltin with ligands based on heterocyclic thioamides (2-
mercaptobenzoxazole, 2-mercaptobenzothiazole, 2-mercaptobenzimidazole) and 2, 6-di-tert …

Unveiling structural features, chemical reactivity, and bioactivity of a newly synthesized purine derivative through crystallography and computational approaches

N Abad, S Buhlak, M Hajji, S Saffour, J Akachar… - Journal of Molecular …, 2024 - Elsevier
We introduce the synthesis and characterization of a novel purine derivative, 2-amino-6‑
chloro-N, N-diphenyl-7H-purine-7-carboxamide. X-ray crystallography was utilized to …

Spectroscopic and computational studies of the biomolecular complex of chemotherapy drug, lomustine and a nucleotide base adenine

C Sonia, N Chetry, TG Devi, T Karlo - Spectroscopy Letters, 2024 - Taylor & Francis
Cancer is still the leading cause of death in both developing and economically developed
countries. There is still a need to create new drugs with higher efficacy despite substantial …

(Z)-N-Carbamoyl-4-hydroxy-4-(4-methoxyphenyl)-2-oxobut-3-enamide

AO Derevnina, AA Andreeva, AN Maslivets - Molbank, 2024 - mdpi.com
The reaction of 5-(4-methoxyphenyl) furan-2, 3-dione with urea in a 1: 1 ratio when refluxed
in a mixture of 1, 2-dichloroethane-DMSO gives (Z)-N-carbamoyl-4-hydroxy-4-(4 …