Cancer epigenetics in clinical practice
V Davalos, M Esteller - CA: a cancer journal for clinicians, 2023 - Wiley Online Library
Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …
Liquid biopsy of methylation biomarkers in cell-free DNA
H Luo, W Wei, Z Ye, J Zheng, R Xu - Trends in molecular medicine, 2021 - cell.com
Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …
[HTML][HTML] Single cell cancer epigenetics
M Casado-Pelaez, A Bueno-Costa, M Esteller - Trends in Cancer, 2022 - cell.com
Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
[HTML][HTML] Polyphenols as potent epigenetics agents for cancer
Human diseases such as cancer can be caused by aberrant epigenetic regulation.
Polyphenols play a major role in mammalian epigenome regulation through mechanisms …
Polyphenols play a major role in mammalian epigenome regulation through mechanisms …
[HTML][HTML] Small extracellular vesicles in cancer
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …
[HTML][HTML] Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder
JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …
outcomes in children with a commonality in deficits in social communication and language …
Airway smooth muscle pathophysiology in asthma
B Camoretti-Mercado, RF Lockey - Journal of Allergy and Clinical …, 2021 - Elsevier
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …
constitutes an important target for treatment. These cells control muscle tone and thus …
[HTML][HTML] DNA methylation in solid tumors: functions and methods of detection
A Martisova, J Holcakova, N Izadi, R Sebuyoya… - International Journal of …, 2021 - mdpi.com
DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …
[HTML][HTML] Methylation biomarkers for early cancer detection and diagnosis: Current and future perspectives
J Ibrahim, M Peeters, G Van Camp… - European Journal of …, 2023 - Elsevier
The increase in recent scientific studies on cancer biomarkers has brought great new
insights into the field. Moreover, novel technological breakthroughs such as long read …
insights into the field. Moreover, novel technological breakthroughs such as long read …
[HTML][HTML] Human papillomavirus E6 and E7: What remains?
A Vats, O Trejo-Cerro, M Thomas, L Banks - Tumour virus research, 2021 - Elsevier
Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us
huge amounts of data on their expression, functions and structures. We know much about …
huge amounts of data on their expression, functions and structures. We know much about …