Genetic and immunological pathogenesis of atopic dermatitis
CF Schuler IV, LC Tsoi, AC Billi, PW Harms… - Journal of Investigative …, 2023 - Elsevier
Type 2 immune–mediated diseases give a clear answer to the issue of nature (genetics)
versus nurture (environment). Both genetics and environment play vital complementary roles …
versus nurture (environment). Both genetics and environment play vital complementary roles …
Autoreactive IgE: pathogenic role and therapeutic target in autoimmune diseases
N Charles, I Kortekaas‐Krohn, E Kocaturk, J Scheffel… - Allergy, 2023 - Wiley Online Library
Autoimmunity is the break of tolerance to self‐antigens that leads to organ‐specific or
systemic diseases often characterized by the presence of pathogenic autoreactive …
systemic diseases often characterized by the presence of pathogenic autoreactive …
Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study
W Zhou, J Cai, Z Li, Y Lin - Frontiers in Immunology, 2023 - frontiersin.org
Background Observational studies have suggested the association between atopic
dermatitis (AD) and the risks of autoimmune diseases. It is still unclear, however, whether or …
dermatitis (AD) and the risks of autoimmune diseases. It is still unclear, however, whether or …
Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes
F Lu, B Wu, Y Wang - BMC Medical Genomics, 2023 - Springer
Background An association has been indicated between atopic dermatitis (AD), a prevalent
chronic inflammatory skin disease, and diabetes mellitus. However, the exact causal …
chronic inflammatory skin disease, and diabetes mellitus. However, the exact causal …
Regulatory T cells in allergic inflammation
Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental
interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory …
interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory …
The last step to achieve barrier damage control
Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes
have been identified. Both innate and adaptive immunity contribute to the …
have been identified. Both innate and adaptive immunity contribute to the …
[HTML][HTML] Exosomes: The emerging mechanisms and potential clinical applications in dermatology
H Yu, H Feng, H Zeng, Y Wu, Q Zhang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Skin tissue, composed of epidermis, dermis, and subcutaneous tissue, is the largest organ of
the human body. It serves as a protective barrier against pathogens and physical trauma …
the human body. It serves as a protective barrier against pathogens and physical trauma …
Investigating Vα7.2+/CD161− T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis
This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.
2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for …
2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for …
Adipose tissue-derived exosomes alleviate particulate matter-induced inflammatory response and skin barrier damage in atopic dermatitis-like triple-cell model
YJ Roh, YH Choi, SH Shin, MK Lee, YJ Won, JH Lee… - Plos one, 2024 - journals.plos.org
Recently, particulate matter (PM) has been shown to exacerbate atopic dermatitis (AD) by
inducing an inflammatory response. Meanwhile, several studies revealed that exosomes …
inducing an inflammatory response. Meanwhile, several studies revealed that exosomes …
New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell era
L Wang, B Wang, E Kou, L Du, Y Zhu - Frontiers in Immunology, 2023 - frontiersin.org
The skin is exposed to environmental challenges and contains heterogeneous cell
populations such as epithelial cells, stromal cells, and skin-resident immune cells. As the …
populations such as epithelial cells, stromal cells, and skin-resident immune cells. As the …