Trends in kinase drug discovery: targets, indications and inhibitor design
The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …
Nanotechnological approaches in prostate cancer therapy: integration of engineering and biology
Nanocarriers have received special attention in biomedicine for the treatment of various
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
Anticancer drugs in wastewater and natural environments: A review on their occurrence, environmental persistence, treatment, and ecological risks
A Castellano-Hinojosa, MJ Gallardo-Altamirano… - Journal of Hazardous …, 2023 - Elsevier
The consumption of anticancer drugs (also known as chemotherapy drugs or antineoplastic
drugs) has augmented over the last decades due to increased cancer incidence. Although …
drugs) has augmented over the last decades due to increased cancer incidence. Although …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
[HTML][HTML] Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer
Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to
numerous structurally and functionally different chemotherapeutic agents. MDR is …
numerous structurally and functionally different chemotherapeutic agents. MDR is …
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy
Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFRWT and EGFRT790M Inhibitors: Microwave-Assisted Synthesis …
A new series of benzimidazole, 1, 2, 4-triazole, and 1, 3, 5-triazine derivatives were
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …
Synthesis and characterization of novel thiazole derivatives as potential anticancer agents: Molecular docking and DFT studies
New thiazole derivatives (2a-l) were synthesized via the reaction of 2-(3-cyano-4-
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …
isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The …
New therapeutic approaches to Parkinson's disease targeting GBA, LRRK2 and Parkin
K Senkevich, U Rudakou, Z Gan-Or - Neuropharmacology, 2022 - Elsevier
Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …
[HTML][HTML] Targeting lysyl oxidase family meditated matrix cross-linking as an anti-stromal therapy in solid tumours
Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …