Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

As a chronic metabolic disease, diabetes mellitus (DM) creates a hyperglycemic micromilieu
around implants, resulting inthe high complication and failure rate of implantation because …

Recent studies have revealed the vital role of MSCs in bone regeneration. In both self-
healing bone regeneration processes and biomaterial-induced healing of bone defects …

Abstract N6-methyladenosine (m6A) modification plays a crucial role in the progression of
osteoporosis (OP). The study aimed to explore the effects of methyltransferase-like 3 …

Ethnopharmacological relevance Tiger bone, which had long been used in traditional
Chinese medicine, had the action of removing wind and alleviating pain, strengthening the …

Oxidative stress is implicated in osteoarthritis, and nuclear factor erythroid 2–related factor 2
(Nrf2)/antioxidant response element (ARE) pathway maintains redox homeostasis. We …

Our study was performed to investigate whether the Wingless and int-1 (Wnt) signaling
pathway promotes osteogenic differentiation and inhibits apoptosis in bone marrow …

Background More and more studies have confirmed that miRNAs play an important role in
maintaining bone remodeling and bone metabolism. This study investigated the expression …

Inhibition of LSD1 was proposed as promising and attractive therapies for treating
osteoporosis. Here, we synthesized a series of novel TCP-(MP)-Caffeic acid analogs as …

Osteoporosis (OP) is a prevalent physiological bone disorder that attribute to elevated bone
absorption and disrupted bone formation. Accumulating evidence has reported that …