Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, B Zhang… - Molecular cancer, 2021 - Springer
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …
phenotypic and functional heterogeneity, are the most essential components of the tumor …
Lactate in the tumour microenvironment: From immune modulation to therapy
ZH Wang, WB Peng, P Zhang, XP Yang, Q Zhou - EBioMedicine, 2021 - thelancet.com
Disordered metabolic states, which are characterised by hypoxia and elevated levels of
metabolites, particularly lactate, contribute to the immunosuppression in the tumour …
metabolites, particularly lactate, contribute to the immunosuppression in the tumour …
A framework for advancing our understanding of cancer-associated fibroblasts
E Sahai, I Astsaturov, E Cukierman… - Nature Reviews …, 2020 - nature.com
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …
[HTML][HTML] Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
D Chen, X Zhang, Z Li, B Zhu - Theranostics, 2021 - ncbi.nlm.nih.gov
Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …
Cancer-associated adipocytes: key players in breast cancer progression
Q Wu, B Li, Z Li, J Li, S Sun, S Sun - Journal of hematology & oncology, 2019 - Springer
Adipocytes are one of the primary stromal cells in many tissues, and they are considered to
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …
The biology and function of fibroblasts in cancer
R Kalluri - Nature Reviews Cancer, 2016 - nature.com
Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …
Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon
TP Brown, V Ganapathy - Pharmacology & therapeutics, 2020 - Elsevier
Reprogramming of biochemical pathways is a hallmark of cancer cells, and generation of
lactic acid from glucose/glutamine represents one of the consequences of such metabolic …
lactic acid from glucose/glutamine represents one of the consequences of such metabolic …
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
P Sansone, C Savini, I Kurelac… - Proceedings of the …, 2017 - National Acad Sciences
The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit
from dormancy have never been investigated. Here we identified the full mitochondrial …
from dormancy have never been investigated. Here we identified the full mitochondrial …
Cancer metabolism: a therapeutic perspective
UE Martinez-Outschoorn, M Peiris-Pagés… - Nature reviews Clinical …, 2017 - nature.com
Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …
distinct from that of their normal counterparts—is growing. In general, tumour cells …