The multi-partner consortium to expand dementia research in Latin America (ReDLat): driving multicentric research and implementation science

A Ibanez, JS Yokoyama, KL Possin, D Matallana… - Frontiers in …, 2021 - frontiersin.org
Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or
declining rates in North America and Europe. This scenario places unprecedented clinical …

Whole-brain network models: from physics to bedside

A Pathak, D Roy, A Banerjee - Frontiers in Computational …, 2022 - frontiersin.org
Computational neuroscience has come a long way from its humble origins in the pioneering
work of Hodgkin and Huxley. Contemporary computational models of the brain span multiple …

Functional geometry of the cortex encodes dimensions of consciousness

Z Huang, GA Mashour, AG Hudetz - Nature communications, 2023 - nature.com
Consciousness is a multidimensional phenomenon, but key dimensions such as awareness
and wakefulness have been described conceptually rather than neurobiologically. We …

[HTML][HTML] The non-specific matrix thalamus facilitates the cortical information processing modes relevant for conscious awareness

EJ Müller, BR Munn, MJ Redinbaugh, J Lizier… - Cell reports, 2023 - cell.com
The neurobiological mechanisms of arousal and anesthesia remain poorly understood.
Recent evidence highlights the key role of interactions between the cerebral cortex and the …

Unifying turbulent dynamics framework distinguishes different brain states

A Escrichs, YS Perl, C Uribe, E Camara… - Communications …, 2022 - nature.com
Significant advances have been made by identifying the levels of synchrony of the
underlying dynamics of a given brain state. This research has demonstrated that non …

Whole-brain models to explore altered states of consciousness from the bottom up

R Cofré, R Herzog, PAM Mediano, J Piccinini… - Brain Sciences, 2020 - mdpi.com
The scope of human consciousness includes states departing from what most of us
experience as ordinary wakefulness. These altered states of consciousness constitute a …

Neuromodulatory control of complex adaptive dynamics in the brain

JM Shine - Interface focus, 2023 - royalsocietypublishing.org
How is the massive dimensionality and complexity of the microscopic constituents of the
nervous system brought under sufficiently tight control so as to coordinate adaptive …

Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness

R Panda, A Thibaut, A Lopez-Gonzalez, A Escrichs… - Elife, 2022 - elifesciences.org
Understanding recovery of consciousness and elucidating its underlying mechanism is
believed to be crucial in the field of basic neuroscience and medicine. Ideas such as the …

Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness

AI Luppi, PAM Mediano, FE Rosas, J Allanson… - Communications …, 2022 - nature.com
The human brain entertains rich spatiotemporal dynamics, which are drastically
reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness …

Model-based whole-brain perturbational landscape of neurodegenerative diseases

YS Perl, S Fittipaldi, CG Campo, S Moguilner, J Cruzat… - Elife, 2023 - elifesciences.org
The treatment of neurodegenerative diseases is hindered by lack of interventions capable of
steering multimodal whole-brain dynamics towards patterns indicative of preserved brain …