[HTML][HTML] The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
M Juarez, A Schcolnik-Cabrera… - American journal of …, 2018 - ncbi.nlm.nih.gov
Drug repositioning is a highly studied alternative strategy to discover and develop
anticancer drugs. This drug development approach identifies new indications for existing …
anticancer drugs. This drug development approach identifies new indications for existing …
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …
Old wine in new bottles: Drug repurposing in oncology
M Antoszczak, A Markowska, J Markowska… - European Journal of …, 2020 - Elsevier
Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …
of de novo development of new anticancer drugs have prompted the pharmaceutical …
[HTML][HTML] ReDO_DB: the repurposing drugs in oncology database
P Pantziarka, C Verbaanderd, V Sukhatme… - …, 2018 - ncbi.nlm.nih.gov
Repurposing is a drug development strategy that seeks to use existing medications for new
indications. In oncology, there is an increased level of activity looking at the use of non …
indications. In oncology, there is an increased level of activity looking at the use of non …
Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells
S Mazumder, R De, S Debsharma, S Bindu… - Journal of Biological …, 2019 - ASBMB
The subcellular mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce
apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse …
apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse …
Drug combination and repurposing for cancer therapy: the example of breast cancer
AS Correia, F Gärtner, N Vale - Heliyon, 2021 - cell.com
Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it
affects and kills millions of people worldwide, being the subject of intense study both in its …
affects and kills millions of people worldwide, being the subject of intense study both in its …
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment
SM Sousa, CPR Xavier… - Current Topics in …, 2023 - ingentaconnect.com
Drug repurposing is a strategy used to develop new treatments based on approved or
investigational drugs outside the scope of their original clinical indication. Since this …
investigational drugs outside the scope of their original clinical indication. Since this …
Current state and outlook for drug repositioning anticipated in the field of ovarian cancer
Y Kobayashi, K Banno, H Kunitomi… - Journal of …, 2019 - synapse.koreamed.org
Ovarian cancer is the seventh most common cancer and the eighth most common cause of
cancer mortality in women. Although standard chemotherapy is the established treatment for …
cancer mortality in women. Although standard chemotherapy is the established treatment for …
“Hard” drug repurposing for precision oncology: the missing link?
P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …
Novel strategies for cancer combat: Drug combination using repurposed drugs induces synergistic growth inhibition of MCF-7 breast and HT-29 colon cancer cells
Our group developed a new model of drug combination consisting of the use of
antineoplastic drugs and different repurposed drugs, having demonstrated that antimalarial …
antineoplastic drugs and different repurposed drugs, having demonstrated that antimalarial …