[HTML][HTML] The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug

M Juarez, A Schcolnik-Cabrera… - American journal of …, 2018 - ncbi.nlm.nih.gov
Drug repositioning is a highly studied alternative strategy to discover and develop
anticancer drugs. This drug development approach identifies new indications for existing …

Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches

F Ahmed, IS Kang, KH Kim, A Asif… - Journal of Medical …, 2023 - Wiley Online Library
Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …

Old wine in new bottles: Drug repurposing in oncology

M Antoszczak, A Markowska, J Markowska… - European Journal of …, 2020 - Elsevier
Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …

[HTML][HTML] ReDO_DB: the repurposing drugs in oncology database

P Pantziarka, C Verbaanderd, V Sukhatme… - …, 2018 - ncbi.nlm.nih.gov
Repurposing is a drug development strategy that seeks to use existing medications for new
indications. In oncology, there is an increased level of activity looking at the use of non …

Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells

S Mazumder, R De, S Debsharma, S Bindu… - Journal of Biological …, 2019 - ASBMB
The subcellular mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce
apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse …

Drug combination and repurposing for cancer therapy: the example of breast cancer

AS Correia, F Gärtner, N Vale - Heliyon, 2021 - cell.com
Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it
affects and kills millions of people worldwide, being the subject of intense study both in its …

Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment

SM Sousa, CPR Xavier… - Current Topics in …, 2023 - ingentaconnect.com
Drug repurposing is a strategy used to develop new treatments based on approved or
investigational drugs outside the scope of their original clinical indication. Since this …

Current state and outlook for drug repositioning anticipated in the field of ovarian cancer

Y Kobayashi, K Banno, H Kunitomi… - Journal of …, 2019 - synapse.koreamed.org
Ovarian cancer is the seventh most common cancer and the eighth most common cause of
cancer mortality in women. Although standard chemotherapy is the established treatment for …

“Hard” drug repurposing for precision oncology: the missing link?

P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …

Novel strategies for cancer combat: Drug combination using repurposed drugs induces synergistic growth inhibition of MCF-7 breast and HT-29 colon cancer cells

D Duarte, I Guerreiro, N Vale - Current Issues in Molecular Biology, 2022 - mdpi.com
Our group developed a new model of drug combination consisting of the use of
antineoplastic drugs and different repurposed drugs, having demonstrated that antimalarial …