Sialic acids (SA) are a kind of nine-carbon backbone sugars, serving as important molecules
in cell-to-cell or cell-to-extra-cellular matrix interaction mediated by either O-linked …

This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

The structure of a sialoglycan can be translated into to a biological response when it binds to
a specific endogenous lectin. Among endogenous sialic acid-binding lectins in humans are …

The Golgi-sialyltransferase ST6Gal1 (βgalactosidase α2, 6 sialyltransferase 1), adds the
negatively charged sugar, sialic acid, to the terminal galactose of N-glycosylated proteins …

Upregulation of surface expressed sialoglycans on tumor cells is one of the mechanisms
which promote tumor growth and progression. Specifically, the interactions of sialic acids …

Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate
cancer. Sialyltransferases have been shown across several solid tumours, including breast …

Background Ovarian cancer (OC) is the most fatal gynaecological malignancy and has a
poor prognosis. Glycosylation, the biosynthetic process that depends on specific …

Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the
surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine …

While inhibitory Siglec receptors are known to regulate myeloid cells, less is known about
their expression and function in lymphocytes subsets. Here we identified Siglec-7 as a glyco …