Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Astragali Radix (Huangqi) is mainly distributed in the Northern Hemisphere, South America,
and Africa and rarely in North America and Oceania. It has long been used as an …

Melatonin confers cardioprotective effects on multiple cardiovascular diseases, including
doxorubicin-induced cardiomyopathy. The effectiveness of melatonin in mitigating …

Background Excessive myocardial fibrosis is the pathological basis of heart failure following
myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac …

Currently, chemotherapy is the main treatment for tumors, but there are still problems such
as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious …

Background As a common cerebrovascular disease (CVD) of the elderly, ischemic stroke
(IS) is characterized by high disability and mortality. Excessive autophagy induced by IS is …

Polyguluronic acid (PG), a polysaccharide from alginate, possesses excellent bioactivities.
We prepared high-purity PG with 10.41 kDa molecular weight (Mw) and a 59 average …

Isoflavones are rich natural compounds present in legumes and are essential for plant
growth and development. Moreover, they are beneficial for animals and humans …

The aberration of programmed cell death including cell death associated with
autophagy/mitophagy, apoptosis, necroptosis, pyroptosis, and ferroptosis can be observed …