Going viral: The role of mobile genetic elements in bacterial immunity
Bacteriophages and other mobile genetic elements (MGEs) pose a significant threat to
bacteria, subjecting them to constant attacks. In response, bacteria have evolved a …
bacteria, subjecting them to constant attacks. In response, bacteria have evolved a …
Retron-Eco1 assembles NAD+-hydrolyzing filaments that provide immunity against bacteriophages
A Carabias, S Camara-Wilpert, MR Mestre… - Molecular Cell, 2024 - cell.com
Retrons are toxin-antitoxin systems protecting bacteria against bacteriophages via abortive
infection. The Retron-Eco1 antitoxin is formed by a reverse transcriptase (RT) and a non …
infection. The Retron-Eco1 antitoxin is formed by a reverse transcriptase (RT) and a non …
Interpretable machine learning reveals a diverse arsenal of anti-defenses in bacterial viruses
A Lopatina, M Ferenc, N Bartlau, M Wolfram… - bioRxiv, 2024 - biorxiv.org
Antagonistic interactions with viruses are an important driver of the ecology and evolution of
bacteria, and associating genetic signatures to these interactions is of fundamental …
bacteria, and associating genetic signatures to these interactions is of fundamental …
Phages reconstitute NAD+ to counter bacterial immunity
Bacteria defend against phage infection via a variety of antiphage defense systems. Many
defense systems were recently shown to deplete cellular nicotinamide adenine dinucleotide …
defense systems were recently shown to deplete cellular nicotinamide adenine dinucleotide …
Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements
V Mateo Caceres, M Redrejo Rodriguez - bioRxiv, 2024 - biorxiv.org
Defense genes gather in diverse types of genomic islands in bacteria and provide immunity
against viruses and other genetic mobile elements. Here, we disclose pipolins, previously …
against viruses and other genetic mobile elements. Here, we disclose pipolins, previously …