Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular
components and recycles metabolic substrates. In response to stress signals in the tumour …

Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive …

Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer;
however, the majority of patients do not respond to ICB therapy. We show that metastatic …

Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes
and to carry out their clearance by dismemberment in the course of catabolic processes in …

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism
and cope with microenvironmental perturbations. Moreover, autophagy connects cellular …

Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …

Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather
antigens and danger signals derived from microbes and tissue. Subsequently, DCs integrate …

Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …