Cancer cell identity and plasticity are required in transition states, such as epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET), in primary …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor
development from initiation to metastasis. EMT could be regarded as a continuum, with …

Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …

Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of
the world's population. Approximately 20% of the infected patients develop gastric ulcers or …

Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to
peritoneal metastasis. GC patients with malignant ascites have a rapidly deteriorating …

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1
(PD-1) are inhibitory checkpoints that are commonly seen on activated T cells and have …

The response to immune checkpoint inhibitors (ICIs) monotherapy remains unsatisfactory in
patients with NSCLC. Thus, combining ICIs with other potential modalities is of great …

Epithelial-to-mesenchymal transition or transformation (EMT) is a cell shape-changing
process that is utilized repeatedly throughout embryogenesis and is critical to the attainment …

Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate
in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that …