Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules
including reactive oxygen and nitrogen species, and antioxidant defenses, has been …

Uric acid is the final product of purine metabolism in humans. The final two reactions of its
production catalyzing the conversion of hypoxanthine to xanthine and the latter to uric acid …

In human and experimental myocardial infarction (MI), cessation of blood supply leads to
rapid necrosis of cardiac myocytes in the ischaemic heart. Immediately after injury, various …

The complex physiological signal transduction networks that respond to the dual challenges
of inflammatory and oxidative stress are major factors that promote the development of …

Background—Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular
redox and survival by suppressing mitochondrial reactive oxygen species generation and by …

Background: Metabolic syndrome is a combination of dysregulated cardiometabolic risk
factors characterized by dyslipidemia, impaired glucose tolerance, insulin resistance …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

Oxidative and inflammatory stresses are cardinal in the pathogenesis of hypertension and
atherosclerosis. Oxidative stress also leads to the induction of inflammation through the …

Background microRNAs (miRNAs) are a class of small, non-coding endogenous RNAs that
post-transcriptionally regulate some protein-coding genes. miRNAs play an important role in …

Uric acid (UA) is the final product of purine catabolism in man, and it is excreted mainly by
the kidneys when renal function is not impaired. Consequently, serum (S) UA increases as a …