[HTML][HTML] Natural therapeutics and nutraceuticals for lung diseases: traditional significance, phytochemistry, and pharmacology

MM Rahman, S Bibi, MS Rahaman, F Rahman… - Biomedicine & …, 2022 - Elsevier
Background Lung diseases including chronic obstructive pulmonary disease (COPD),
infections like influenza, acute respiratory distress syndrome (ARDS), asthma and …

Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics

S Li, J Shi, H Tang - Cell Biology And Toxicology, 2022 - Springer
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
progressive loss of pulmonary function. Drug-induced interstitial lung disease has been …

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

R Boudewijns, HJ Thibaut, SJF Kaptein, R Li… - Nature …, 2020 - nature.com
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2− infected hamsters, whereas hydroxychloroquine lacks activity

SJF Kaptein, S Jacobs, L Langendries… - Proceedings of the …, 2020 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the
globe after its emergence in Wuhan in December 2019. With no specific therapeutic and …

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

L Sanchez-Felipe, T Vercruysse, S Sharma, J Ma… - Nature, 2021 - nature.com
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the
development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are …

An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis

RG Jenkins, BB Moore, RC Chambers… - American journal of …, 2017 - atsjournals.org
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

R Abdelnabi, R Boudewijns, CS Foo, L Seldeslachts… - …, 2021 - thelancet.com
Background Within one year after its emergence, more than 108 million people acquired
SARS-CoV-2 and almost 2· 4 million succumbed to COVID-19. New SARS-CoV-2 variants of …

PM2. 5 induced pulmonary fibrosis in vivo and in vitro

Z Xu, Z Li, Z Liao, S Gao, L Hua, X Ye, Y Wang… - Ecotoxicology and …, 2019 - Elsevier
Epidemiological studies have revealed positive correlation between particulate matter with
an aerodynamic diameter of< 2.5 µm (PM 2.5) and pulmonary fibrosis (PF). As etiology and …

Quantification of lung fibrosis in IPF-like mouse model and pharmacological response to treatment by micro-computed tomography

F Ruscitti, F Ravanetti, V Bertani, L Ragionieri… - Frontiers in …, 2020 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive degenerative lung disease
leading to respiratory failure and death. Although anti-fibrotic drugs are now available for …

Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice

M Zaw Thin, C Moore, T Snoeks, T Kalber… - Nature …, 2023 - nature.com
X-ray computed tomography is a reliable technique for the detection and longitudinal
monitoring of pulmonary nodules. In preclinical stages of diagnostic or therapeutic …