[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines

NM Selby, MW Taal - Diabetes, Obesity and Metabolism, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is a major healthcare challenge. It occurs in up to 50% of those
living with diabetes, is a major cause of end‐stage kidney disease (ESKD) that requires …

Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury

R Qi, C Yang - Cell death & disease, 2018 - nature.com
Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all
progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide …

[HTML][HTML] Diabetic kidney disease: challenges, advances, and opportunities

Y Chen, K Lee, Z Ni, JC He - Kidney diseases, 2020 - karger.com
Background: Diabetic kidney disease (DKD) is the most common cause of the end-stage
renal disease (ESRD). Regardless of intensive treatments with hyperglycemic control, blood …

Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy

C Grange, S Tritta, M Tapparo, M Cedrino, C Tetta… - Scientific reports, 2019 - nature.com
Extracellular vesicles (EVs) that are derived from mesenchymal stromal cells (MSCs) have
been shown to reprogram injured cells by activating regenerative processes. We herein …

Development and internal validation of machine learning algorithms for end-stage renal disease risk prediction model of people with type 2 diabetes mellitus and …

Y Zou, L Zhao, J Zhang, Y Wang, Y Wu, H Ren… - Renal failure, 2022 - Taylor & Francis
Aims Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease
(ESRD) and is associated with increased morbidity and mortality in patients with diabetes …

Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets

J Barrera‐Chimal, F Jaisser - Diabetes, Obesity and …, 2020 - Wiley Online Library
Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

Omentin-1: a newly discovered warrior against metabolic related diseases

A Zhao, H Xiao, Y Zhu, S Liu, S Zhang… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Chronic metabolism-related diseases are challenging clinical problems.
Omentin-1 is mainly expressed in stromal vascular cells of adipose tissue and can also be …

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

SMW Yu, JV Bonventre - Current opinion in nephrology and …, 2020 - journals.lww.com
Acute kidney injury and maladaptive tubular repair leading t... : Current Opinion in Nephrology
and Hypertension Acute kidney injury and maladaptive tubular repair leading to renal fibrosis …

Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

S Shi, S Lei, C Tang, K Wang, Z Xia - Bioscience reports, 2019 - portlandpress.com
Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury,
which is associated with increased oxidative stress and impaired nuclear factor erythroid 2 …