Myocardial fatigue: a mechano-energetic concept in heart failure
P Tran, H Maddock, P Banerjee - Current Cardiology Reports, 2022 - Springer
Abstract Purpose of Review This review combines existing mechano-energetic principles to
provide a refreshing perspective in heart failure (HF) and examine if the phenomenon of …
provide a refreshing perspective in heart failure (HF) and examine if the phenomenon of …
Solving a century-old conundrum underlying cardiac force-length relations
JC Han, T Pham, AJ Taberner… - American Journal of …, 2019 - journals.physiology.org
In the late 19th century, Otto Frank presented a diagram (Frank O. Z Biol 37: 483–526, 1899)
showing that cardiac end-systolic pressure-volume relations are dependent on the mode of …
showing that cardiac end-systolic pressure-volume relations are dependent on the mode of …
Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans
E Pueyo, M Orini, JF Rodríguez, P Taggart - Journal of molecular and …, 2016 - Elsevier
Ventricular repolarization dynamics are crucial to arrhythmogenesis. Low-frequency
oscillations of repolarization have recently been reported in humans and the magnitude of …
oscillations of repolarization have recently been reported in humans and the magnitude of …
Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists
FS Ahmad, Y Jin, A Grassam-Rowe… - … of the Royal …, 2023 - royalsocietypublishing.org
Atrial fibrillation (AF) is the most common chronic arrhythmia presenting a heavy disease
burden. We report a new approach for generating cardiomyocytes (CMs) resembling atrial …
burden. We report a new approach for generating cardiomyocytes (CMs) resembling atrial …
Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors
S Oda, K Nishiyama, Y Furumoto, Y Yamaguchi… - Nature …, 2022 - nature.com
Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve
activation is important for cardiocirculatory homeostasis. Transient receptor potential …
activation is important for cardiocirculatory homeostasis. Transient receptor potential …
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General …
BD Guth, M Engwall, S Eldridge, CM Foley… - Frontiers in …, 2019 - frontiersin.org
Drug-induced effects on cardiac contractility can be assessed through the measurement of
the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious …
the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious …
Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular …
O Friedrich, D Schneidereit, YA Nikolaev… - Progress in biophysics …, 2017 - Elsevier
Hollow organs (eg heart) experience pressure-induced mechanical wall stress sensed by
molecular mechano-biosensors, including mechanosensitive ion channels, to translate into …
molecular mechano-biosensors, including mechanosensitive ion channels, to translate into …
Profiling the biomechanical responses to workload on the human myocyte to explore the concept of myocardial fatigue and reversibility: rationale and design of the …
P Tran, A Linekar, U Dandekar, T Barker… - Journal of …, 2024 - Springer
It remains unclear why some patients develop heart failure without evidence of structural
damage. One theory relates to impaired myocardial energetics and ventricular-arterial …
damage. One theory relates to impaired myocardial energetics and ventricular-arterial …
Time course of low-frequency oscillatory behavior in human ventricular repolarization following enhanced sympathetic activity and relation to arrhythmogenesis
DA Sampedro-Puente, J Fernandez-Bes… - Frontiers in …, 2020 - frontiersin.org
Background and Objectives: Recent studies in humans and dogs have shown that
ventricular repolarization exhibits a low-frequency (LF) oscillatory pattern following …
ventricular repolarization exhibits a low-frequency (LF) oscillatory pattern following …
Understanding spatiotemporal mechanical behavior, viscoelasticity, and functions of stem cell-derived cardiomyocytes
L Lou, AS Rubfiaro, J He, A Agarwal - Nanoscale, 2023 - pubs.rsc.org
Understanding myocytes' spatiotemporal mechanical behavior and viscoelasticity is a long-
standing challenge as it plays a critical role in regulating structural and functional …
standing challenge as it plays a critical role in regulating structural and functional …