Nerve growth factor (NGF) was the first neurotrophin described. This neurotrophin
contributes to organogenesis by promoting sensory innervation and angiogenesis in the …

Background Insulin resistance (IR) is a condition in which the response of organs to insulin
is impaired. IR is an early marker of metabolic dysfunction. However, IR also appears in …

The nerve growth factor (NGF) participates in cell survival and glucose-stimulated insulin
secretion (GSIS) processes in rat adult beta cells. GSIS is a complex process in which …

Pancreatic beta cells during the first month of development acquire functional maturity,
allowing them to respond to variations in extracellular glucose concentration by secreting …

Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is
preceded by a phase of intense proliferation. These events occurring in the neonatal period …

In this chapter, we describe the methods used to culture mainly rat pancreatic beta cells. We
consider necessary to use this approach to get more information about physiological …

In vitro produced β-like cells can provide promising cell therapy for curing the epidemic of
diabetes. In this context, we aimed to investigate the effects of different concentrations of γ …

Weaning is a crucial period for the development of the full glucose-stimulated insulin
secretion (GSIS) response, since β-cell is challenged by switching from high-milk fat diet to …

La insulina es una hormona anabólica producida por las células β pancreáticas. Una de sus
principales funciones es mantener la homeostasis de la glucosa. Además, la sensibilidad a …

Glucose-induced insulin secretion, a peculiar property of fully mature β-cells, is only
achieved after birth and is preceded by a phase of intense proliferation. These events …