Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

The cellular lives of Wolbachia

J Porter, W Sullivan - Nature Reviews Microbiology, 2023 - nature.com
Wolbachia are successful Gram-negative bacterial endosymbionts, globally infecting a large
fraction of arthropod species and filarial nematodes. Efficient vertical transmission, the …

A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …

R Khandia, M Dadar, A Munjal, K Dhama, K Karthik… - Cells, 2019 - mdpi.com
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Evolutionary Ecology of Wolbachia Releases for Disease Control

PA Ross, M Turelli, AA Hoffmann - Annual review of genetics, 2019 - annualreviews.org
Wolbachia is an endosymbiotic Alphaproteobacteria that can suppress insect-borne
diseases through decreasing host virus transmission (population replacement) or through …

Mosquito trilogy: microbiota, immunity and pathogens, and their implications for the control of disease transmission

P Gabrieli, S Caccia, I Varotto-Boccazzi… - Frontiers in …, 2021 - frontiersin.org
In mosquitoes, the interaction between the gut microbiota, the immune system, and the
pathogens that these insects transmit to humans and animals is regarded as a key …

Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila

JD Shropshire, SR Bordenstein - PLoS genetics, 2019 - journals.plos.org
Wolbachia are maternally inherited bacteria that infect arthropod species worldwide and are
deployed in vector control to curb arboviral spread using cytoplasmic incompatibility (CI). CI …

Impact of the microbiome on mosquito-borne diseases

H Shi, X Yu, G Cheng - Protein & Cell, 2023 - academic.oup.com
Mosquito-borne diseases present a significant threat to human health, with the possibility of
outbreaks of new mosquito-borne diseases always looming. Unfortunately, current …

The Antiviral Effects of the Symbiont Bacteria Wolbachia in Insects

AC Pimentel, CS Cesar, M Martins… - Frontiers in immunology, 2021 - frontiersin.org
Wolbachia is a maternally transmitted bacterium that lives inside arthropod cells. Historically,
it was viewed primarily as a parasite that manipulates host reproduction, but more recently it …

Wolbachia: endosymbiont of onchocercid nematodes and their vectors

RRS Manoj, MS Latrofa, S Epis, D Otranto - Parasites & vectors, 2021 - Springer
Background Wolbachia is an obligate intracellular maternally transmitted, gram-negative
bacterium which forms a spectrum of endosymbiotic relationships from parasitism to …

Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens

R Zheng, Q Wang, R Wu, PN Paradkar… - The ISME …, 2023 - academic.oup.com
Mosquito-borne diseases like dengue and malaria cause a significant global health burden.
Unfortunately, current insecticides and environmental control strategies aimed at the vectors …