Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

The Notch signaling pathway is an ancient and highly conserved signaling pathway that
controls cell fate specification and tissue patterning in the embryo and in the adult. Region …

Left ventricular noncompaction (LVNC) causes prominent ventricular trabeculations and
reduces cardiac systolic function. The clinical presentation of LVNC ranges from …

Esta atualização da Diretriz de Insuficiência Cardíaca Crônica (IC)-2012 surge para
reavaliar as recomendações através de uma avaliação criteriosa das pesquisas …

Embolism of cardiac origin accounts for around 15–30% of ischaemic strokes. Strokes due
to cardioembolism are generally severe and early and long-term recurrence and mortality …

Ventricular chambers are essential for the rhythmic contraction and relaxation occurring in
every heartbeat throughout life. Congenital abnormalities in ventricular chamber formation …

Background: Left ventricular (LV) trabeculation is highly variable among individuals and is
increased in some diseases (eg, congenital heart disease or cardiomyopathies), but its …

During the past two decades, numerous disease-causing genes for different
cardiomyopathies have been identified. These discoveries have led to better understanding …