During the last decade, biological therapies have an increasing share in the modern
therapeutics of various diseases including inflammatory bowel diseases (IBD). Animal …

Due to its extremely pleiotropic nature, the complex effects of IFN-γ exerted both on immune
and non-immune cell types still remain only partially understood. The longstanding view of …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …

Many trials of mesenchymal stem cells (MSCs) have been published in the past 5–6 y.
MSCs inhibit T-cell alloreactivity in vitro by soluble factors and direct cell-to-cell contact …

The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor
κB (NF-κB)–dependent cytokine expression, is involved in the regulation of inflammation …

Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in
immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells …

Cardiac transplantation is the most effective treatment for advanced heart failure. Despite
improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts …

T cells play a pivotal role in the immune response underlying inflammatory bowel disease
(IBD) pathogenesis. On this basis, over the past 25 years several drugs have assessed to …

Abstract Prolonged Ca 2+ entry through Ca 2+ release-activated Ca 2+(CRAC) channels is
crucial in activating the Ca 2+-sensitive transcription factor NFAT, which is responsible for …

The maintenance and regulation of the barrier function of the epithelial lining of the intestine
are important homeostatic events, serving to allow selective absorption from the gut lumen …