The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases
During the last decade, biological therapies have an increasing share in the modern
therapeutics of various diseases including inflammatory bowel diseases (IBD). Animal …
therapeutics of various diseases including inflammatory bowel diseases (IBD). Animal …
The tolerogenic role of IFN-γ
Due to its extremely pleiotropic nature, the complex effects of IFN-γ exerted both on immune
and non-immune cell types still remain only partially understood. The longstanding view of …
and non-immune cell types still remain only partially understood. The longstanding view of …
[HTML][HTML] Interleukin-12 and Th1 immune response in Crohn's disease: Pathogenetic relevance and therapeutic inplication
I Peluso, F Pallone, G Monteleone - World journal of …, 2006 - ncbi.nlm.nih.gov
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …
Role of mesenchymal stem cell therapy in Crohn's disease
Many trials of mesenchymal stem cells (MSCs) have been published in the past 5–6 y.
MSCs inhibit T-cell alloreactivity in vitro by soluble factors and direct cell-to-cell contact …
MSCs inhibit T-cell alloreactivity in vitro by soluble factors and direct cell-to-cell contact …
Autoregulation of Th1-mediated inflammation by twist1
U Niesner, I Albrecht, M Janke, C Doebis… - The Journal of …, 2008 - rupress.org
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor
κB (NF-κB)–dependent cytokine expression, is involved in the regulation of inflammation …
κB (NF-κB)–dependent cytokine expression, is involved in the regulation of inflammation …
NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine
A Bai, A Moss, S Rothweiler, M Serena Longhi… - Nature …, 2015 - nature.com
Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in
immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells …
immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells …
Interferon-γ axis in graft arteriosclerosis
G Tellides, JS Pober - Circulation research, 2007 - Am Heart Assoc
Cardiac transplantation is the most effective treatment for advanced heart failure. Despite
improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts …
improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts …
Targeting T cells in inflammatory bowel disease
P Giuffrida, A Di Sabatino - Pharmacological Research, 2020 - Elsevier
T cells play a pivotal role in the immune response underlying inflammatory bowel disease
(IBD) pathogenesis. On this basis, over the past 25 years several drugs have assessed to …
(IBD) pathogenesis. On this basis, over the past 25 years several drugs have assessed to …
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
A Di Sabatino, L Rovedatti, R Kaur… - The Journal of …, 2009 - journals.aai.org
Abstract Prolonged Ca 2+ entry through Ca 2+ release-activated Ca 2+(CRAC) channels is
crucial in activating the Ca 2+-sensitive transcription factor NFAT, which is responsible for …
crucial in activating the Ca 2+-sensitive transcription factor NFAT, which is responsible for …
Interferon-γ regulation of intestinal epithelial permeability
C Beaurepaire, D Smyth, DM McKay - Journal of Interferon and …, 2009 - liebertpub.com
The maintenance and regulation of the barrier function of the epithelial lining of the intestine
are important homeostatic events, serving to allow selective absorption from the gut lumen …
are important homeostatic events, serving to allow selective absorption from the gut lumen …