Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update
A Dahan, GL Amidon… - Expert review of clinical …, 2010 - Taylor & Francis
The therapeutic management of inflammatory bowel disease (IBD) represents the perfect
scenario for drug targeting to the site (s) of action. While existing formulation-based targeting …
scenario for drug targeting to the site (s) of action. While existing formulation-based targeting …
Not all monoclonals are created equal–lessons from failed drug trials in Crohn's disease
A Kaser - Best Practice & Research Clinical Gastroenterology, 2014 - Elsevier
The recent success of the anti-integrin antibody Vedolizumab can barely conceal the fact
that the biologics armamentarium in Crohn's disease has barely evolved beyond TNF …
that the biologics armamentarium in Crohn's disease has barely evolved beyond TNF …
[HTML][HTML] Interleukin-12 family cytokines and sarcoidosis
S Ringkowski, PS Thomas, C Herbert - Frontiers in Pharmacology, 2014 - frontiersin.org
Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is
believed to be caused by exposure to pathogenic antigens in genetically susceptible …
believed to be caused by exposure to pathogenic antigens in genetically susceptible …
Efficacy and safety of interferon-gamma-targeted therapy in Crohn's disease: a systematic review and meta-analysis of randomized controlled trials
D Cui, G Huang, D Yang, B Huang, B An - Clinics and research in …, 2013 - Elsevier
Aims To evaluate the efficacy and safety of interferon-gamma-targeted therapy in Crohn's
disease (CD). Methods Keyword and MeSH searches of MEDLINE/PubMed, EMBASE, the …
disease (CD). Methods Keyword and MeSH searches of MEDLINE/PubMed, EMBASE, the …
Interfering with interferons in inflammatory bowel disease
S Ghosh, R Chaudhary, M Carpani, R Playford - Gut, 2006 - gut.bmj.com
Interferons (IFN) are cytokines pro-duced by immune cells in response to virus, bacteria,
parasites, and tumour cells. Interferons exhibit immunomodulatory and antitumour activity in …
parasites, and tumour cells. Interferons exhibit immunomodulatory and antitumour activity in …
What's the next best cytokine target in IBD?
TT MacDonald, P Biancheri, M Sarra… - Inflammatory bowel …, 2012 - academic.oup.com
In the gut of patients with inflammatory bowel disease (IBD), immune and nonimmune cells
produce large amounts of cytokines that drive the inflammatory process leading to the tissue …
produce large amounts of cytokines that drive the inflammatory process leading to the tissue …
Advances in biologic therapy for ulcerative colitis and Crohn's disease
G D'Haens, M Daperno - Current gastroenterology reports, 2006 - Springer
The medical management of inflammatory bowel disease (IBD) has changed considerably
since the advent of biologic treatments. In this review we offer a critical evaluation of …
since the advent of biologic treatments. In this review we offer a critical evaluation of …
[HTML][HTML] Sistema imunitário: parte III. O delicado equilíbrio do sistema imunológico entre os pólos de tolerância e autoimunidade
AWS Souza, D Mesquita Júnior, JAP Araújo… - Revista Brasileira de …, 2010 - SciELO Brasil
O sistema imunológico é constituído por uma intrincada rede de órgãos, células e
moléculas e tem por finalidade manter a homeostase do organismo, combatendo as …
moléculas e tem por finalidade manter a homeostase do organismo, combatendo as …
Pharmacokinetic and Pharmacodynamic Relationship of AMG 811, An Anti-IFN-γ IgG1 Monoclonal Antibody, in Patients with Systemic Lupus Erythematosus
P Chen, T Vu, A Narayanan, W Sohn, J Wang… - Pharmaceutical …, 2015 - Springer
Purpose To investigate the relationships between AMG 811 exposure, concentration
changes in serum IFN-γ, and IFN-γ-induced protein 10 (CXCL10), and to identify important …
changes in serum IFN-γ, and IFN-γ-induced protein 10 (CXCL10), and to identify important …
[HTML][HTML] Model-based meta-analysis on the efficacy of biologics and small targeted molecules for Crohn's disease
B Yu, L Zhao, S Jin, H He, J Zhang, X Wang - Frontiers in Immunology, 2022 - frontiersin.org
Information on comparative drug efficacy is of great importance for drug development as well
as clinical practice. Up to now, the relative efficacy of biologics and small targeted molecules …
as clinical practice. Up to now, the relative efficacy of biologics and small targeted molecules …