Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Chronic diseases claim millions of lives every year, and it is of great significance to explore
and develop advanced drugs to improve the cure rate of chronic diseases. Nanotheranostics …

PCIF1 can mediate the methylation of N 6, 2′-O-dimethyladenosine (m6Am) in mRNA. Yet,
the detailed interplay between PCIF1 and the potential cofactors and its pathological …

In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

Dynamic variations in the concentration and abnormal distribution of endogenous
biomarkers are strongly associated with multiple physiological and pathological states …

hydroxymethylcytosine (5hmC) is a key epigenetic mark in the mammalian genome that has
been proposed as a promising cancer biomarker with diagnostic and prognostic potentials …

Oncogenic imbalance of DNA methylation is well recognized in cancer development. The
ten-eleven translocation (TET) family of dioxygenases, which facilitates DNA demethylation …