Platform trials bring the promise of making clinical research more efficient and more patient
centric. While their use has become more widespread, including their prominent role during …

Background Platform trials gained popularity during the last few years as they increase
flexibility compared to multi-arm trials by allowing new experimental arms entering when the …

Background Platform trials can evaluate the efficacy of several experimental treatments
compared to a control. The number of experimental treatments is not fixed, as arms may be …

Abstract The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a
multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus …

Background The evidence for whether ivermectin impacts recovery, hospital admissions,
and longer-term outcomes in COVID-19 is contested. The WHO recommends its use only in …

There has been an increasing use of master protocols in oncology clinical trials because of
its efficiency to accelerate cancer drug development and flexibility to accommodate multiple …

Abstract The Platform trial In COVID-19 priming and BOOsting (PICOBOO) is a multi-site,
adaptive platform trial designed to generate evidence of the immunogenicity, reactogenicity …

Large randomised trials provide the most reliable evidence of effectiveness of new
treatments in clinical practice. However, the time and resources required to complete such …

Although platform trials have many benefits, the complexity of these designs may result not
only in increased methodological but also regulatory and ethical challenges. These aspects …

Background A platform trial approach allows adding arms to on-going trials to speed up
intervention discovery programs. A control arm remains open for recruitment in a platform …