SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and …

L Østergaard - Physiological reports, 2021 - Wiley Online Library
Abstract Corona virus disease 2019 (COVID‐19) causes symptoms from multiple organs
after infection by severe acute respiratory syndrome corona virus 2 (SARS CoV‐2). They …

Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

D De Backer, D Orbegozo Cortes, K Donadello… - Virulence, 2014 - Taylor & Francis
Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the various mechanisms that are potentially …

[HTML][HTML] Mechanosensing and mechanoregulation of endothelial cell functions

Y Fang, D Wu, KG Birukov - Comprehensive physiology, 2019 - ncbi.nlm.nih.gov
Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Microcirculatory alterations: potential mechanisms and implications for therapy

D De Backer, K Donadello, FS Taccone… - Annals of intensive …, 2011 - Springer
Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the characteristics of these alterations, the …

Sepsis and major abdominal surgery lead to flaking of the endothelial glycocalix

J Steppan, S Hofer, B Funke, T Brenner… - Journal of Surgical …, 2011 - Elsevier
BACKGROUND: Recent evidence suggests that the endothelial glycocalix plays an
important role in lethal outcomes following sepsis. We therefore tested if the endothelial …

Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion

DH Lee, MJC Dane, BM Van Den Berg, MGS Boels… - PloS one, 2014 - journals.plos.org
Changes in endothelial glycocalyx are one of the earliest changes in development of
cardiovascular disease. The endothelial glycocalyx is both an important biological modifier …

Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass

NAM Dekker, D Veerhoek, NJ Koning… - …, 2019 - Wiley Online Library
We investigated microcirculatory perfusion disturbances following cardiopulmonary bypass
in the early postoperative period and whether the course of these disturbances mirrored …

Fluid management in sepsis: The potential beneficial effects of albumin

JL Vincent, D De Backer, CJ Wiedermann - Journal of critical care, 2016 - Elsevier
Fluid administration is a key intervention in hemodynamic resuscitation. Timely expansion
(or restoration) of plasma volume may prevent tissue hypoxia and help to preserve organ …

Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress

X Marechal, R Favory, O Joulin, D Montaigne… - Shock, 2008 - journals.lww.com
The glycocalyx constitutes the first line of the blood tissue interface and is thus involved in
many physiological processes, deregulation of which may lead to microvascular dysfunction …

Coupling microcirculation to systemic hemodynamics

D De Backer, JA Ortiz, D Salgado - Current opinion in critical care, 2010 - journals.lww.com
Coupling microcirculation to systemic hemodynamics : Current Opinion in Critical Care
Coupling microcirculation to systemic hemodynamics : Current Opinion in Critical Care Log in or …