Endothelial and microcirculatory function and dysfunction in sepsis

JF Colbert, EP Schmidt - Clinics in chest medicine, 2016 - chestmed.theclinics.com
The microcirculation, comprised of less than 100 μm–diameter arterioles, capillary beds, and
draining venules, performs essential homeostatic functions, including oxygen delivery and …

Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability

M Nieuwdorp, MC Meuwese… - Journal of applied …, 2008 - journals.physiology.org
The endothelial glycocalyx is increasingly considered as an intravascular compartment that
protects the vessel wall against pathogenic insults. The purpose of this study was to …

The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases

HH Lipowsky - Annals of biomedical engineering, 2012 - Springer
The endothelial cell (EC) surface is coated with a layer of polysaccharides linked to
membrane-bound and trans-membrane proteoglycans that comprise the glycocalyx, which …

Evaluation of resuscitation fluids on endothelial glycocalyx, venular blood flow, and coagulation function after hemorrhagic shock in rats

LN Torres, JL Sondeen, L Ji, MA Dubick… - Journal of Trauma …, 2013 - journals.lww.com
BACKGROUND Endothelial glycocalyx (EG) plays an essential role in endothelium integrity
and may be compromised by hemorrhagic shock. The effects of currently available …

The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness

D Chappell, M Westphal, M Jacob - Current Opinion in …, 2009 - journals.lww.com
The impact of the glycocalyx on microcirculatory oxygen dist... : Current Opinion in
Anesthesiology The impact of the glycocalyx on microcirculatory oxygen distribution in critical …

Endothelial activation and microcirculatory disorders in sepsis

L Raia, L Zafrani - Frontiers in Medicine, 2022 - frontiersin.org
The vascular endothelium is crucial for the maintenance of vascular homeostasis. Moreover,
in sepsis, endothelial cells can acquire new properties and actively participate in the host's …

Advanced age results in a diminished endothelial glycocalyx

DR Machin, SI Bloom, RA Campbell… - American Journal …, 2018 - journals.physiology.org
Age-related microvascular dysfunction is well characterized in rodents and humans, but little
is known about the properties of the microvascular endothelial glycocalyx in advanced age …

Peritubular capillary rarefaction: an underappreciated regulator of CKD progression

Y Kida - International Journal of Molecular Sciences, 2020 - mdpi.com
Peritubular capillary (PTC) rarefaction is commonly detected in chronic kidney disease
(CKD) such as hypertensive nephrosclerosis and diabetic nephropathy. Moreover, PTC …

Tumor necrosis factor-α inhibition protects against endotoxin-induced endothelial glycocalyx perturbation

M Nieuwdorp, MC Meuwese, HL Mooij… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: Inflammatory stimuli profoundly increase the vulnerability of the vessel wall to
atherogenesis. The endothelial glycocalyx, a layer of glycosaminoglycans and …

Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapies

M Miranda, M Balarini, D Caixeta… - American Journal of …, 2016 - journals.physiology.org
Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …