Acute hyperglycemia exacerbates trauma-induced endothelial and glycocalyx injury: an in vitro model

LN Diebel, ME Diebel, JV Martin… - Journal of Trauma and …, 2018 - journals.lww.com
BACKGROUND Early hyperglycemia is associated with higher mortality in trauma and
predicts multiple organ failure. Endothelial cell (EC) injury and glycocalyx (GC) degradation …

No‐reflow phenomenon and endothelial glycocalyx of microcirculation

AV Maksimenko, AD Turashev - Biochemistry research …, 2012 - Wiley Online Library
The progress in reperfusion therapy dictated the necessity for developing new tools and
procedures for adjacent/additional therapy of acute cardiovascular disorders. The adjacent …

Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

J van Haare, ME Kooi, JWGE van Teeffelen… - Cardiovascular …, 2017 - Springer
Background Disturbances in coronary microcirculatory function, such as the endothelial
glycocalyx, are early hallmarks in the development of obesity and insulin resistance …

Microcirculatory monitoring in children with congenital heart disease before and after cardiac surgery

Ö Erdem, JC de Graaff, MP Hilty, US Kraemer… - Journal of …, 2023 - Springer
In this prospective observational study, we investigated whether congenital heart disease
(CHD) affects the microcirculation and whether the microcirculation is altered following …

Cardiovascular responses during sepsis

M Pecchiari, K Pontikis, E Alevrakis… - Comprehensive …, 2021 - air.unimi.it
Sepsis is the life-threatening organ dysfunction arising from a dysregulated host response to
infection. Although the specific mechanisms leading to organ dysfunction are still debated …

Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis

S Grundmann, SH Schirmer… - Journal of cellular …, 2009 - Wiley Online Library
During collateral artery growth, monocytes adhere to the endothelium and secrete cytokines
from the perivascular space promoting arteriogenesis. Recently, the endothelial glycocalyx …

Clinical management of the cardiovascular failure in sepsis

D De Backer, S Scolletta - Current vascular pharmacology, 2013 - ingentaconnect.com
Cardiovascular failure in sepsis involves a combination of hypovolemia, decreased vascular
tone, myocardial depression and microcirculatory alterations. Fluids represent the first line …

Alterations of conjunctival glycocalyx and microcirculation in non-septic critically ill patients

A Pranskunas, T Tamosuitis, N Balciuniene… - Microvascular …, 2018 - Elsevier
As of now the relationship between glycocalyx degradation and microcirculatory perfusion
abnormalities in non-septic critical ill patients is unclear. In addition, conjunctival sidestream …

[HTML][HTML] The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections

B Ćurko-Cofek, M Jenko, G Taleska Stupica… - International Journal of …, 2024 - mdpi.com
Since its introduction, the number of heart surgeries has risen continuously. It is a high-risk
procedure, usually involving cardiopulmonary bypass, which is associated with an …

Agonist-induced impairment of glycocalyx exclusion properties: contribution to coronary effects of adenosine

JWGE VanTeeffelen, J Brands… - Cardiovascular research, 2010 - academic.oup.com
The endothelial glycocalyx is the negatively charged, gel-like mesh residing at the luminal
side of the vascular endothelium and forming the interface between the flowing blood and …