α-Synuclein in synaptic function and dysfunction
Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …
physiological conditions, it binds to synaptic vesicle membranes and functions in …
[HTML][HTML] Aggregation of disordered proteins associated with neurodegeneration
Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …
[HTML][HTML] Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
[HTML][HTML] Flanking regions, amyloid cores, and polymorphism: the potential interplay underlying structural diversity
AA Bhopatkar, R Kayed - Journal of Biological Chemistry, 2023 - ASBMB
The β-sheet–rich amyloid core is the defining feature of protein aggregates associated with
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease
J Gasparotto, N Somensi, CS Girardi… - Journal of …, 2023 - Wiley Online Library
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that
belongs to the immunoglobulin superfamily and is extensively associated with chronic …
belongs to the immunoglobulin superfamily and is extensively associated with chronic …
Key genes and convergent pathogenic mechanisms in Parkinson disease
Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …
[HTML][HTML] Brain clearance of protein aggregates: a close-up on astrocytes
Protein misfolding and accumulation defines a prevailing feature of many
neurodegenerative disorders, finally resulting in the formation of toxic intra-and extracellular …
neurodegenerative disorders, finally resulting in the formation of toxic intra-and extracellular …
[HTML][HTML] Alpha synuclein post translational modifications: potential targets for Parkinson's disease therapy?
V Brembati, G Faustini, F Longhena… - Frontiers in molecular …, 2023 - frontiersin.org
Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …
symptoms. The neuropathological alterations characterizing the brain of patients with PD …
[HTML][HTML] Pathological relevance of post-translationally modified alpha-synuclein (pSer87, pSer129, nTyr39) in idiopathic Parkinson's disease and multiple system …
B Sonustun, MF Altay, C Strand, K Ebanks… - Cells, 2022 - mdpi.com
Aggregated alpha-synuclein (α-synuclein) is the main component of Lewy bodies (LBs),
Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological …
Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological …
[HTML][HTML] Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon
Increasing evidence suggests that the gut–brain axis plays a crucial role in Parkinson's
disease (PD). The abnormal accumulation of aggregated alpha-synuclein (aSyn) in the …
disease (PD). The abnormal accumulation of aggregated alpha-synuclein (aSyn) in the …