Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Accumulation of amyloid-β (Aβ) and Tau is an invariant feature of Alzheimer disease (AD).
The upstream role of Aβ accumulation in the disease pathogenesis is widely accepted, and …

Autophagy, the major degradative pathway for organelles and long-lived proteins, is
essential for the survival of neurons. Mounting evidence has implicated defective autophagy …

Mitochondria are uniquely poised to play a pivotal role in neuronal cell survival or death
because they are regulators of both energy metabolism and cell death pathways. Extensive …

Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the
hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, the reverse …

Alzheimer's disease (AD) is the most common type of dementia which characterized by a
progressive loss of memory and cognitive function due to degeneration of synapses and …