RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand–receptor interactions
PV Groomes, U Kanjee, MT Duraisingh - Trends in parasitology, 2022 - cell.com
A critical step in malaria blood-stage infections is the invasion of red blood cells (RBCs) by
merozoite forms of the Plasmodium parasite. Much progress has been made in defining the …
merozoite forms of the Plasmodium parasite. Much progress has been made in defining the …
How genetics might explain the unusual link between malaria and COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated coronavirus
disease 2019 (COVID-19) pandemic has been the subject of a large number of studies in …
disease 2019 (COVID-19) pandemic has been the subject of a large number of studies in …
Common host variation drives malaria parasite fitness in healthy human red cells
The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes
severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are …
severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are …
P. falciparum Invasion and Erythrocyte Aging
MF Alves-Rosa, NM Tayler, D Dorta, LM Coronado… - Cells, 2024 - mdpi.com
Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose
receptors for the pathogen ligands and, on the other hand, maintain the right geometry to …
receptors for the pathogen ligands and, on the other hand, maintain the right geometry to …
The awesome power of human genetics of infectious disease
Since the identification of sickle cell trait as a heritable form of resistance to malaria,
candidate gene studies, linkage analysis paired with sequencing, and genome-wide …
candidate gene studies, linkage analysis paired with sequencing, and genome-wide …
Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon
Recent data suggest that only a small fraction of severe malaria heritability is explained by
the totality of genetic markers discovered so far. The extensive genetic diversity within …
the totality of genetic markers discovered so far. The extensive genetic diversity within …
A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis
Background'Benign ethnic neutropenia'(BEN) is a heritable condition characterized by lower
neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic …
neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic …
Mouse models for unravelling immunology of blood stage malaria
AC Olatunde, DH Cornwall, M Roedel, TJ Lamb - Vaccines, 2022 - mdpi.com
Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …
participant in malarial disease. This is particularly true in relation to the immune responses …
Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria
S Nisar, M Torres, A Thiam, B Pouvelle… - International Journal of …, 2022 - mdpi.com
Genome-wide association studies for severe malaria (SM) have identified 30 genetic
variants mostly located in non-coding regions. Here, we aimed to identify potential causal …
variants mostly located in non-coding regions. Here, we aimed to identify potential causal …
Proteome of stored RBC membrane and vesicles from heterozygous beta thalassemia donors
VL Tzounakas, AT Anastasiadi… - International Journal of …, 2021 - mdpi.com
Genetic characteristics of blood donors may impact the storability of blood products. Despite
higher basal stress, red blood cells (RBCs) from eligible donors that are heterozygous for …
higher basal stress, red blood cells (RBCs) from eligible donors that are heterozygous for …