Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study

SN Kariuki, JJ Gilchrist, S Uyoga… - The Journal of …, 2024 - academic.oup.com
Abstract Background The Dantu blood group variant protects against Plasmodium
falciparum infections, but its wider consequences have not been previously explored. Here …

Biophysical tools and concepts enable understanding of asexual blood stage malaria

V Introini, MA Govendir, JC Rayner, P Cicuta… - Frontiers in Cellular …, 2022 - frontiersin.org
Forces and mechanical properties of cells and tissues set constraints on biological functions,
and are key determinants of human physiology. Changes in cell mechanics may arise from …

Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria

A Pance, BL Ng, K Mwikali, M Koutsourakis… - Frontiers in Cellular …, 2023 - frontiersin.org
Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant
stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the …

Two prevalent∼ 100-kb GYPB deletions causative of the GPB-Deficient blood group MNS phenotype S–s–U–in black Africans

C Gassner, GA Denomme, C Portmann… - Transfusion Medicine …, 2020 - karger.com
The U antigen (MNS5) is one of 49 antigens belonging to the MNS blood group system
(ISBT002) carried on glycophorins A (GPA) and B (GPB). U is present on the red blood cells …

From Genome-wide Association Studies to Functional Variants: ARL14 Cis-regulatory Variants Are Associated With Severe Malaria

M Adjemout, F Gallardo, M Torres… - The Journal of …, 2024 - academic.oup.com
Background Genome-wide association studies have identified several nonfunctional tag
single-nucleotide polymorphisms (SNPs) associated with severe malaria. We hypothesized …

Limited genetic variations of the Rh5-CyRPA-Ripr invasion complex in Plasmodium falciparum parasite population in selected malaria-endemic regions, Kenya

H Waweru, BN Kanoi, JO Kuja, M Maranga… - Frontiers in tropical …, 2023 - frontiersin.org
The invasion of human erythrocytes by Plasmodium falciparum merozoites requires
interaction between parasite ligands and host receptors. Interaction of Pf Rh5-CyRPA-Ripr …

Risk score prediction model based on single nucleotide polymorphism for predicting malaria: a machine learning approach

KY Tai, J Dhaliwal, KS Wong - BMC bioinformatics, 2022 - Springer
Background The malaria risk prediction is currently limited to using advanced statistical
methods, such as time series and cluster analysis on epidemiological data. Nevertheless …

Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults

F Joof, E Hartmann, A Jarvis, A Colley, JH Cross… - Malaria journal, 2023 - Springer
Abstract Background Polymorphisms in ATP2B4 coding for PMCA4b, the primary regulator
of erythrocyte calcium concentration, have been shown by GWAS and cross-sectional …

[HTML][HTML] A Whole-Genome Scan Revealed Genomic Features and Selection Footprints of Mengshan Cattle

H Cheng, Y Lyu, Z Liu, C Li, K Qu, S Li, Z Ahmed, W Ma… - Genes, 2024 - mdpi.com
(1) Background: Mengshan cattle from the Yimeng mountainous region in China stand out
as a unique genetic resource, known for their adaptive traits and environmental resilience …

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

M Koch, J Cegla, B Jones, Y Lu, Z Mallat… - Malaria journal, 2019 - Springer
Background Malaria disease commences when blood-stage parasites, called merozoites,
invade human erythrocytes. Whilst the process of invasion is traditionally seen as being …