Background TP53 has been shown to play a role in inflammatory processes, including
malaria. We previously found that p53 attenuates parasite-induced inflammation and …

Background Malaria caused by P. falciparum imposes a tremendous public health burden
on people living in sub-Saharan Africa. Severe malaria is associated with high morbidity and …

Malaria is a vector-borne infection common in tropical and subtropical countries. The
immunological reactions warranted by the malaria Plasmodium falciparum parasite occur …

Plasmodium falciparum interacts with several human cell types during their complex life
cycle, including erythrocytes and hepatocytes. The enuclated nature of erythrocytes makes …

Background Using indicators of disease severity, clinicians can predict which Plasmodium
falciparum (Pf) malaria patients being treated with artesunate or quinine are likely to die …

Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in
hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high …

Background Inducible expression of heme oxygenase-1 (encoded by the gene HMOX1)
may determine protection from heme released during malaria infections. A variable length …

Background Genome-wide association studies have identified ATP2B4 as a severe malaria
resistance gene. Recently, 8 potential causal regulatory variants have been shown to be …

Background Cerebral malaria (CM) is a preeminent cause of severe disease and premature
deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of …

Single nucleotide polymorphisms (SNPs) in the β-like globin gene of the human hosts to the
risk of malaria are unclear. Therefore, this study investigates these associations in the …