Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …

Cardiac arrhythmia occurs frequently worldwide, and in severe cases can be fatal.
Mitochondria are the power plants of cardiomyocytes. In recent studies, mitochondria under …

Previous studies, including our own, have demonstrated that transient receptor potential
vanilloid 4 (TRPV4) is expressed in hearts and implicated in cardiac remodeling and …

Background Structural and electrophysiological remodeling characterize heart failure (HF)
enhancing arrhythmias. PKD1 (protein kinase D1) is upregulated in HF and mediates …

Prolonged stimulation of β-adrenergic receptor (β-AR) can lead to sympathetic overactivity
that causes pathologic cardiac hypertrophy and fibrosis, ultimately resulting in heart failure …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

Here we present a deep learning-based image analysis platform (DLAP), tailored to
autonomously quantify cell numbers, and fluorescence signals within cellular compartments …

We reported that A-kinase anchoring protein 5 (AKAP5) played a role in cardiomyocyte
apoptosis after hypoxia-reoxygenation (H/R). The role of AKAP5 in cardiomyocyte …

Stachydrine hydrochloride (Sta), an activated alkaloid, is isolated from traditional Chinese
medicine Yimucao. In previous studies, the cardioprotective effects of Sta were found in our …

Vascular smooth muscle cells (VSMCs) help to maintain the normal physiological
contractility of arterial vessels to control blood pressure; they can also contribute to vascular …