Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production
Using a unique resource of samples from a controlled human malaria infection (CHMI)
study, we identified a novel population of CD4+ T cells whose frequency in the peripheral …
study, we identified a novel population of CD4+ T cells whose frequency in the peripheral …
Associating immunotherapy and targeted therapies: facts and hopes
Abstract Immune-checkpoint inhibitors (ICI), particularly inhibitors of the PD-1/PD-L1
(Programmed Death 1/Programmed Death-Ligand 1) axis, have modified the management …
(Programmed Death 1/Programmed Death-Ligand 1) axis, have modified the management …
[HTML][HTML] Safety, pharmacokinetics, and pharmacodynamics of ME-401, an oral, potent, and selective inhibitor of phosphatidylinositol 3-kinase P110δ, following single …
Purpose ME-401 is a novel selective inhibitor of phosphatidylinositol 3 kinase p110δ, an
enzyme often found overexpressed and overactive in B-cell malignancies. The current study …
enzyme often found overexpressed and overactive in B-cell malignancies. The current study …
CD38 as an immunomodulator in cancer
Y Li, R Yang, L Chen, S Wu - Future Oncology, 2020 - Taylor & Francis
CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human
tissues and cells, especially those in the immune system. CD38 protein was previously …
tissues and cells, especially those in the immune system. CD38 protein was previously …
Recycling endosome-dependent and-independent mechanisms for IL-10 secretion in LPS-activated macrophages
Two post-Golgi pathways where IL-10 is trafficked, ensures its secretion from activated
macrophages under different physiological conditions. IL-10 is a key anti-inflammatory …
macrophages under different physiological conditions. IL-10 is a key anti-inflammatory …
[HTML][HTML] Loss of phosphatidylinositol 3-kinase activity in regulatory T cells leads to neuronal inflammation
AK Stark, E Davenport, DT Patton… - The Journal of …, 2020 - journals.aai.org
Abstract Class I PI3K enzymes are critical for the maintenance of effective immunity. In T
cells, PI3Kα and PI3Kδ are activated by the TCR and costimulatory receptors, whereas …
cells, PI3Kα and PI3Kδ are activated by the TCR and costimulatory receptors, whereas …
Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
M Uehara, MM McGrath, S Ohori, Z Solhjou… - Nature …, 2017 - nature.com
Abstract Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in
leukocytes, and defects in these signaling pathways have been shown to impair T cell …
leukocytes, and defects in these signaling pathways have been shown to impair T cell …
[HTML][HTML] PI3Kδ regulates the magnitude of CD8+ T cell responses after challenge with Listeria monocytogenes
VQ Pearce, H Bouabe, AR MacQueen… - The Journal of …, 2015 - journals.aai.org
PI3Ks regulate diverse immune cell functions by transmitting intracellular signals from Ag,
costimulatory receptors, and cytokine receptors to control cell division, differentiation …
costimulatory receptors, and cytokine receptors to control cell division, differentiation …
CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism
S García-Rodríguez, A Rosal-Vela, D Botta… - Scientific reports, 2018 - nature.com
In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus.
CD38-deficient (Cd38−/−) but not ART2-deficient (Art2−/−) mice developed less severe …
CD38-deficient (Cd38−/−) but not ART2-deficient (Art2−/−) mice developed less severe …
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the
activation of other T cells and antigen presenting cells. The role of phosphoinositide 3 …
activation of other T cells and antigen presenting cells. The role of phosphoinositide 3 …