Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin

D Weinshenker, PV Holmes - Brain research, 2016 - Elsevier
Decades of research confirm that noradrenergic locus coeruleus (LC) neurons are essential
for arousal, attention, motivation, and stress responses. While most studies on LC …

Genetic susceptibility to heroin addiction: a candidate gene association study

O Levran, D Londono, K O'hara… - Genes, Brain and …, 2008 - Wiley Online Library
Heroin addiction is a chronic complex disease with a substantial genetic contribution. This
study was designed to identify genetic variants that are associated with susceptibility to …

[HTML][HTML] Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

A Laque, S Yu, E Qualls-Creekmore, S Gettys… - Molecular …, 2015 - Elsevier
Objective Leptin modulates food reward via central leptin receptor (LepRb) expressing
neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated …

The molecular mechanisms of morphine addiction

CA McClung - Reviews in the Neurosciences, 2006 - degruyter.com
Addiction to opiates such as morphine is a major public health concern. A more thorough
understanding of the molecular mechanisms of opiate addiction can lead to better treatment …

The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder

N Kozlovsky, MA Matar, Z Kaplan, J Zohar, H Cohen - Biological psychiatry, 2009 - Elsevier
BACKGROUND: Converging evidence implicates the regulatory neuropeptide galanin in
anxiety-and depression-related behaviors, through modulation of neuroendocrine …

Stimulation of food intake after central galanin is associated with arcuate nucleus activation and does not differ between genetically selected low and high body weight …

CJ Hagen, BA Newmyer, RI Webster, ER Gilbert… - Neuropeptides, 2013 - Elsevier
Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a
variety of species. In the present study, we investigated appetite-associated effects of …

Receptor subtype‐dependent galanin actions on gamma‐aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala

M Bajo, SG Madamba, X Lu, LM Sharkey… - Addiction …, 2012 - Wiley Online Library
The neuropeptide galanin and its three receptor subtypes (GalR1‐3) are expressed in the
central amygdala (CeA), a brain region involved in stress‐and anxiety‐related behaviors, as …

Cell‐type specific expression and behavioral impact of galanin and GalR1 in the locus coeruleus during opioid withdrawal

SL Foster, E Galaj, SL Karne, S Ferré… - Addiction …, 2021 - Wiley Online Library
The neuropeptide galanin is reported to attenuate opioid withdrawal symptoms, potentially
by reducing neuronal hyperactivity in the noradrenergic locus coeruleus (LC) via galanin …

Galanin and its receptors: Introduction to the Third International Symposium, San Diego, California, USA, 21–22 October 2004

T Hökfelt - Neuropeptides, 2005 - Elsevier
The Third Galanin Symposium presented many different and exciting results on galanin
research reflecting a major progress since the previous symposium in 1998. A major …

Galnon facilitates extinction of morphine-conditioned place preference but also potentiates the consolidation process

X Zhao, K Yun, RR Seese, Z Wang - Plos one, 2013 - journals.plos.org
Learning and memory systems are intimately involved in drug addiction. Previous studies
suggest that galanin, a neuropeptide that binds G-protein coupled receptors, plays essential …