Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …

Serotonin neurons of the dorsal and median raphe nuclei (DR, MR) collectively innervate
the entire forebrain and midbrain, modulating diverse physiology and behavior. To gain a …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Among the brainstem raphe nuclei, the dorsal raphe nucleus (DR) contains the greatest
number of Pet1-lineage neurons, a predominantly serotonergic group distributed throughout …

Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological
and behavioral processes. In spite of the relatively reduced number of serotonin-producing …

The continuing fascination with serotonin (5‐hydroxytryptamine, 5‐HT) as a nervous system
chemical messenger began with its discovery in the brains of mammals in 1953. Among the …

Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R)
in the brain physiology and pathology have advanced considerably in recent years. A wealth …

Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

Serotonin-producing neurons profusely innervate brain regions via long-range projections.
However, it remains unclear whether and how endogenous serotonergic transmission …