Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Cancer immunotherapy using anti‐programmed death‐ligand 1 (PD‐L1) antibodies has
been used in various clinical applications and achieved certain results. However, such …

Metabolic reprogramming plays a crucial role in the development of hepatocellular
carcinoma (HCC). However, the key drivers of metabolic reprogramming underlying HCC …

Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …

The nanotechnology is an interdisciplinary field that has become a hot topic in cancer
therapy. Metal-organic frameworks (MOFs) are porous materials and hybrid composites …

Glioblastoma (GBM) is an aggressive primary CNS malignancy and clinical outcomes have
remained stagnant despite introduction of new treatments. Understanding the tumor …

Introduction Coronavirus disease 2019 (COVID-19) is a global pandemic and highly
contagious, posing a serious threat to human health. Colorectal cancer (CRC) is a risk factor …

Background & Aims Metabolic dysfunction–associated steatohepatitis (MASH) is a common
chronic liver disease worldwide. No effective pharmacologic therapies for MASH have been …

Emerging evidence indicates the critical roles of circular RNAs in the development of
multiple cancers, containing hepatocellular carcinoma (HCC). Herein, our present research …

Abstract Lymphocyte activation gene 3 (LAG3), an immune checkpoint molecule expressed
on activated T cells, functions as a negative regulator of immune responses. Persistent …