The mechanisms by which cells sense their mechanical environment and transduce the
signal through focal adhesions and signaling pathways to the nucleus is an area of key …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

Flow cytometry is used routinely to measure single-cell gene expression by staining cells
with fluorescent antibodies and nucleic acids. Here, we present tension-activated cell …

Amino acids metabolism, especially aspartate metabolism, is often altered in human cancers
including hepatocellular carcinoma (HCC) and this metabolic remodeling is required for …

Background & Aims Fibrosis and tissue stiffening are hallmarks of inflammatory bowel
disease (IBD). We have hypothesized that the increased stiffness directly contributes to the …

The regulation of the intracellular level of ATP is a fundamental aspect of bioenergetics.
Actin cytoskeletal dynamics have been reported to be an energetic drain in developing …

Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs),
whereby a widely expressed protein causes lesions in specific cell types and brain regions …

The failing heart is characterized by elevated levels of reactive oxygen species. We have
developed an animal model of heart failure induced by chemogenetic production of …

Metabolism and mechanics are two key facets of structural and functional processes in cells,
such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has …

Metformin is a clinically-approved anti-diabetic drug with emerging antitumor potential, but
its antitumor activity is highly susceptible to local glucose abundance. Herein, we construct a …