Alcohol dehydrogenases (ADHs) mediated biocatalytic asymmetric reduction of ketones
have been widely applied in the synthesis of optically active secondary alcohols with highly …

Enantiopure vicinal halohydrins (vic-halohydrins) are highly valuable building blocks for the
synthesis of many different natural products and pharmaceuticals, and biocatalytic methods …

Ancestral enzymes are promising for industrial biotechnology due to high stability and
catalytic promiscuity. An effective protocol was developed for the directed resurrection of …

Bioreduction of ketones with self-sufficient cofactor regeneration is green and sustainable for
the synthesis of chiral secondary alcohols. In this study, a novel alcohol dehydrogenase Cg …

Asymmetric bioreduction of ketones is a fundamental process in the production of organic
molecules. Compounds containing tetralone rings are found in the structure of many …

Enzymes are valuable tools to introduce chirality into small molecules. Especially,
ketoreductase (KRED)‐catalyzed transformations of ketones to yield chiral secondary …

Abstract 7β-Hydroxysteroid dehydrogenases (7β-HSDHs) have attracted increasing
attention due to their crucial roles in the biosynthesis of ursodeoxycholic acid (UDCA) …

In this study, chemo-enzymatic synthesis of furfuralcohol from biomass-derived xylose was
successfully demonstrated by a sequential acid-catalyzed dehydration under microwave …

Abstract tert-Butyl (3R, 5S)-6-chloro-3, 5-dihydroxyhexanoate ((3R, 5S)-CDHH) is a key
chiral intermediate for the side chain synthesis of rosuvastatin. In this study, random …

Abstract (R)-Pantolactone (PL) is a key chiral intermediate for the synthesis of calcium (R)-
pantothenate and (R)-panthenol used as food additives. The commercial production of (R) …