Bacterial-and plant-derived immunotoxins have documented potential for treatment of
cancer. We discuss Anthrax toxin, ribosome inactivating-toxins, such as saporin and ricin …

Recombinant immunotoxins (RITs) are chimeric proteins that are being developed for
cancer treatment. We have produced RITs that contain PE38, a portion of the bacterial …

Immunotherapy options for patients with cancer have emerged following decades of
research on immune responses against tumors. Most treatments in this category harness T …

Introduction B-cell activation triggers the release of endoplasmic reticulum calcium stores
through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia in older adults. Although amyloid-beta (Aβ) plaque deposition …

Myasthenia gravis (MG) is characterized by fatigable skeletal muscle weakness with a
fluctuating and unpredictable disease course and is caused by circulating autoantibodies …

Background Alzheimer's disease (AD) is a devastating age-related neurodegenerative
disorder and characterized by progressive loss of memory and cognitive functions, which …

Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that
target structures of the neuromuscular junction. However, some patients also experience …

SARS-CoV-2 antibodies develop within two weeks of infection, but wane relatively rapidly
post-infection, raising concerns about whether antibody responses will provide protection …

This study was performed to determine if developmental exposure of rats to heptachlor (H)
during the last half of gestation through puberty adversely affects adult functioning of the …